Aiming drug discovery at lysophosphatidic acid targets
نویسندگان
چکیده
منابع مشابه
Aiming drug discovery at lysophosphatidic acid targets
Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is the prototype member of a family of lipid mediators and second messengers. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and a nuclear hormone receptor within the cell. In addition, there are several enzymes that utilize LPA as a substrate or generate it as a produc...
متن کاملStructural characteristics of lysophosphatidic acid biological targets.
Lysophosphatidic acid (LPA; 1-acyl-3-phosphoglycerol) exerts its biological activity through both extracellular and intracellular targets. Receptor targets include the cell-surface G-protein-coupled receptors LPA(1-4) and the nuclear PPAR-gamma (peroxisome-proliferator-activated receptor gamma). Enzyme targets include the secreted cancer cell motility factor, autotaxin, and the transmembrane ph...
متن کاملLysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling
The endogenous phospholipid lysophosphatidic acid (LPA) regulates fundamental cellular processes such as proliferation, survival, motility, and invasion implicated in homeostatic and pathological conditions. Hence, delineation of the full range of molecular mechanisms by which LPA exerts its broad effects is essential. We report avid binding of LPA to the receptor for advanced glycation end pro...
متن کاملAiming at New Targets to Achieve Normoglycemia During Pregnancy
In a recent issue of Diabetes Care, Hernandez et al. (1) from the University of Colorado presented a comprehensive review of the 24-h glucose profile during pregnancy in women without diabetes. In the current issue, Harmon et al. (2) from the same institution present new observations on the glycemic profile of pregnant nondiabetic women, examining differences between obese and normal-weight mot...
متن کاملNew Targets for Drug Discovery against Malaria
A mathematical model which predicts the intraerythrocytic stages of Plasmodium falciparum infection was developed using data from malaria-infected mice. Variables selected accounted for levels of healthy red blood cells, merozoite (Plasmodium asexual phase) infected red blood cells, gametocyte (Plasmodium sexual phase) infected red blood cells and a phenomenological variable which accounts for ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2010
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2010.00815.x